S1E05 - Epigenetic Alterations & Nutrient-Sensing Cross-Talk

Season 1: The Science of Aging | Episode 5: Epigenetic Alterations & Nutrient-Sensing Cross-Talk

Dive into the fascinating world of epigenetics, where the seemingly fixed story of your aging is dynamically rewritten by your lifestyle choices. In this episode, we explore the interplay between our genetic blueprint and environmental factors, using compelling twin studies to unveil how identical genetics can diverge dramatically over time.

Gain insights into how our lifestyle, diet, and stress imprint powerful marks on our DNA, influencing gene expression without altering the sequence itself. Discover the breakthroughs of epigenetic clocks, tools measuring biological age and their implications for understanding the aging process.

Join us as we uncover the pivotal role of NAD+ and sirtuins in cellular metabolism and longevity, and dissect the promising interventions aimed at slowing aging by targeting nutrient sensing pathways. From the enzyme CD38 to caloric restriction mimetics, explore the potential for effectively extending your healthspan.